Silica-Gelatin Composite Materials for Prolonged Desorption of Bioactive Compounds

  • Oksana STAVINSKAYA Chuiko Institute of Surface Chemistry NAS of Ukraine
  • Iryna LAGUTA Chuiko Institute of Surface Chemistry NAS of Ukraine
  • Inna OREL Chuiko Institute of Surface Chemistry NAS of Ukraine
Keywords: composite materials, gelatin, silica, bioactive compounds, controlled release

Abstract

The set of gelatin and silica-gelatin films with incorporated bioactive compounds of different chemical nature was prepared. The swelling behavior of the films and desorption of active ingredients into aqueous media were studied. For all the silica-gelatin films we observed considerable improvement of the materials water stability and retardation of the release of bioactive compounds as compared to gelatin samples. The results obtained make it possible to consider silica-gelatin composite materials as promising disintegrating dosage forms for prolonged desorption of bioactive compounds.

DOI: http://dx.doi.org/10.5755/j01.ms.20.2.4966

Published
2014-06-13
Section
POLYMERS AND COMPOSITES, WOOD