Silica-Gelatin Composite Materials for Prolonged Desorption of Bioactive Compounds

Oksana STAVINSKAYA, Iryna LAGUTA, Inna OREL

Abstract


The set of gelatin and silica-gelatin films with incorporated bioactive compounds of different chemical nature was prepared. The swelling behavior of the films and desorption of active ingredients into aqueous media were studied. For all the silica-gelatin films we observed considerable improvement of the materials water stability and retardation of the release of bioactive compounds as compared to gelatin samples. The results obtained make it possible to consider silica-gelatin composite materials as promising disintegrating dosage forms for prolonged desorption of bioactive compounds.

DOI: http://dx.doi.org/10.5755/j01.ms.20.2.4966


Keywords


composite materials; gelatin; silica; bioactive compounds; controlled release

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Print ISSN: 1392–1320
Online ISSN: 2029–7289