Mesoporous Bioactive Glass Doped with Inorganic Compounds: A Promising Approach for Osteosarcoma Applications. Review Article

Abstract

Osteosarcoma treatment requires a multidisciplinary team approach. Standard therapy for localized osteosarcoma includes a combination of chemotherapy and surgical intervention. Survivors require specialized long-term follow-up, as both chemotherapy and surgery may lead to significant and lasting adverse effects on patients’ quality of life. The aim of this article is to explore the potential of innovative osteosarcoma treatment strategies involving bioactive glass. To review the scope of existing studies on the applicability of mesoporous bioactive glass doped with inorganic compounds in osteosarcoma, scientific publications from global sources were analyzed. The literature search was conducted in February and March 2025 using the electronic databases PubMed, Google Scholar, and ResearchGate. A total of 42 full-text articles were identified, with a substantial increase in publications over the past five years, reflecting the growing scientific interest in this topic. Mesoporous bioactive glass represents a specialized class of bioactive materials with excellent capacity for controlled drug release in malignant tumors. This type of glass exhibits structural characteristics similar to mesoporous silicate materials while retaining the compositional features typical of conventional bioactive glasses. The combination of traditional therapy with the synergistic bone-regenerative potential of mesoporous bioactive glass provides a strong foundation for the development of new treatment approaches for bone cancer. Evidence indicates that ions released from mesoporous bioactive glasses demonstrate high therapeutic efficacy in cancer treatment and tissue engineering.